On Steroidal Sapogenins. VI. Synthesis of 11-Oxygenated Spirostanes. (4).
نویسندگان
چکیده
منابع مشابه
Preliminary pharmacobiological study of new steroidal sapogenins.
The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID50 = 5 micrograms/ml). A pharmacodynamic screening carried out on this product ...
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Supplementation of dairy rations with steroidal sapogenins was evaluated in an in vitro, an in situ, and a production trial. Sixteen in vitro semicontinuous rumen cultures were supplied a 55:45 concentrate to roughage substrate with Sarsaponin concentrations of 0, 33, 55, and 77 ppm of air-dry feed for 22 d. Supplementation decreased protozoa numbers and increased bacterial numbers and acid det...
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Syntheses of steroidal heterocycles containing a five-membered N,S- heterocycle attached at the 6,7 positions of the B ring are reported. 5Alpha-cholestane-6-one (1), its 3beta-acetoxy- (2) and 3beta-chloro- (3) analogues reacted with semicarbazide and aqueous sodium acetate in refluxing ethanol to yield 5alpha-cholestan-6-one-semicarbazone 1a and its 3-beta-acetoxy and 3beta-chloro derivatives...
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The plant Dioscorea composita has important applications in the medical and energy industries, and can be used for the extraction of steroidal sapogenins (important raw materials for the synthesis of steroidal drugs) and bioethanol production. However, little is known at the genetic level about how sapogenins are biosynthesized in this plant. Using Illumina deep sequencing, 62,341 unigenes were...
متن کاملSynthesis and Characterization of 4, 11-dimethyl-1, 4, 8, 11, tetraazabicyclo hexadecane Chromium
A new complex of Chromium(III) and the cross-bridged macrocyclic ligand 4,11-dimethyl-1,4,8,11tetraazabicyclo[6.6.2] hexadecane has been synthesized. Complexation of Tungsten, Vanadium, and Molybdenum was unsuccessful. The Cr(III)(L) complex was characterized using UV-Visible spectroscopy λmax = 583nm , IR Spectroscopy, X-Ray Crystallography, and magnetic susceptibility ueff = 3.95. These tests...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1962
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.10.413